Scientists using HIV to treat severe immunodeficiency in 8 children

US scientists have succeeded in using HIV to develop HIV gene therapy in which they were able to cure eight infants infected with severe cases of HIV, or the so-called disease baby bubble boy bubble, where eight children became after treatment have immune to a complete function.

The ‘baby bubble’ situation is different from AIDS, a genetic condition in which a child is born with a disabling immune system. She was named after one of the most famous children, David Vetter, who was transferred 20 seconds after birth to a sterile plastic bag to prevent contact with the bacteria. He spent 6 years in this bag until he was transferred to A special plastic suit designed specifically by NASA. However, the child died at the age of 12 years when doctors attempted to perform a transplant.

As noted above, the current treatments for the disease depends on a bone marrow transplant from donor tissue clique compatible with the textile clique of the patient, but this correspondence histological is not available in 80% of cases, so the transplant performed using stem cells from other donors. However, the likelihood of this treatment failing is great, and it can also have serious side effects.

As for the new treatment, the scientists relied on correcting the genetic defect in bone marrow cells immediately after birth.

After gene repair, it was introduced into a modified version of the HIV virus.

According to doctors, most of the children were discharged from the hospital within a month of the operation.

The operations were carried out at St. Jude Children’s Research Hospital and UCSF Benioff Hospital in San Francisco.

The results of the trial were published in the New England Journal of Medicine.

Source: BBC

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