Researchers have been able to use immune cells capable of removing and destroying HIV from the body’s hiding places, which could mean a full recovery of the condition, no need for more lifelong medication, and a vaccine for the virus.
It is known that the current drugs of the virus reduces the number of the body in the patient, without being eliminated permanently, which requires the patient to use these drugs throughout his life. Although these drugs have helped to reduce the spread of the virus and improved the quality of life of patients, it leaves side effects such as gastrointestinal problems, cardiovascular problems, insulin resistance, hemorrhagic problems and others.
According to the researchers, there are many attempts and research that is currently underway around the world to create a definitive treatment for HIV, which eliminates the use of current ARVs, and most or all of these attempts are based on the principle of ‘kick and kill Kick and Kill’ , Then spend it.
HIV is used to hide in T cells without affecting its whereabouts. The proportion of T cells that contain HIV may not exceed one cell in every 10 million cells, making it difficult or impossible to find a virus-infected cell, which is the main problem in the treatment of AIDS despite the availability of drugs capable of eliminating The virus itself.
To overcome this dilemma, researchers have studied the behavior and similarity of a virus that is different from HIV and is found in 95% of AIDS patients, the cytomegalovirus (CMV).
The researchers have engineered dendritic cells that can detect and activate T cells containing the CMV virus that causes the virus to escape and thus eliminate it easily. They succeeded with HIV as well.
“Through this treatment, we have achieved the principle of ‘kill and warlk’, and this treatment seems to us like a sharp multifunctional knife,” says lead author Dr. Robbie Maylard, professor of infectious diseases and biology at the University of Pittsburgh School of Public Health. We also believe that this is the first treatment based on programmed dendritic cells that employs the CMV virus in the process of extracting HIV from its cache and then eliminating it. ‘
The results of the study were published in EBioMedicine.
Source: Medical News Today